منابع مشابه
Antibodies to Human Growth Hormone (hgh) in Human Subjects Treated with Hgh.
Human growth hormone (HGH) (1, 2) has been used experimentally and therapeutically in man since 1957 (3-5). The metabolic and growth-promoting effects of the parenterally administered hormone in humans (3-5) and the antigenicity of various HGH preparations in rabbits and in guinea pigs (6, 7) are well documented. This paper describes the appearance of specific antibodiesto HGH in the plasma of ...
متن کاملImmunofunctional assay of human growth hormone (hGH) in serum: a possible consensus for quantitative hGH measurement.
Confirmation of the diagnosis of GH deficiency in adults and children involves provocative testing for human (h) GH. Different commercially available immunoassays yield largely discrepant results in the measurement of GH levels in human serum. These discrepancies result in doubtful relevance of cut-off levels proposed for GH provocative testing. We have developed an immunofunctional assay metho...
متن کاملLessons Learned from the hGH Era
Today, many medical interventions that begin as treatments for disease often expand into therapies that reduce disability, lessen disadvantage, or even confer advantage. Forces that propel profitable drugs, devices, and procedures dominate over considerations of efficient and equitable distribution of resources. This dominance is fueled by industry-physician collaborations often biased by prior...
متن کاملThe 20-kilodalton (kDa) human growth hormone (hGH) differs from the 22-kDa hGH in the complex formation with cell surface hGH receptor and hGH-binding protein circulating in human plasma.
In spite of recent advance in understanding of the stoichiometry of 22-kDa human GH (22K-hGH) with cell surface hGH receptor (hGHR) and hGH-binding protein (hGH-BP) circulating in human plasma, that of 20-kDa hGH (20K-hGH) is poorly understood. To clarify this, mouse pro-B Ba/F3 cells stably expressing the full-length hGHR (Ba/F3-hGHR) and both recombinant and native hGH-BP were used in this st...
متن کاملHuman lymphocytes express hGH-N gene transcripts of 22kDa, 20kDa and minor forms of GH, but not hGH-V gene.
Expression of human growth hormone (hGH) in lymphocytes was examined by reverse transcription polymerase chain reaction (RT-PCR) in five normal subjects. Transcripts of hGH-N gene, but not hGH-V gene, were detected. Sequence analysis revealed four kinds of transcripts: 22kDa GH, 20kDa GH and two other forms of variant GH. The 20kDa GH transcript was generated by alternative splicing within exon...
متن کاملShort-term study of biosynthesized hGH in man.
Daily injection of 8IU of methionyl human growth hormone (met-hGH), produced by recombinant DNA technology, was performed in healthy young volunteers. Daily injections for four days did not cause any significant change in the results of physical examination, electrocardiogram, blood count or urinalysis. Non-esterified fatty acid levels increased significantly at 4 hours after the first injectio...
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عنوان ژورنال
دوره 9 شماره 34
صفحات 7- 14
تاریخ انتشار 2007-06-22
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